Prowess trial wiki

The end-organ dysfunction that accompanies severe sepsis and septic shock is in part mediated by a systemic proinflammatory and procoagulant state, leading to the hypothesis that recombinant human activated protein C drotrecogin alfa, DrotAA may improve survival when administered to adults with severe sepsis.

The study was halted early after its second interim analysis revealed a statistically significant survival benefit with DrotAA. In particular, day mortality was Based on this ARR of 6. Since activated protein C promotes fibrinolysis and inhibits thrombosis, it was hypothesized that recombinant human activated protein C drotrecogin alfa, DrotAA may improve survival when administered to patients with severe sepsis.

The mean APACHE II score was 25; most patients had a lactic acidosis that persisted despite aggressive fluid resuscitation; and effectively all patients had multiorgan dysfunction.

However, at an interim efficacy analysis, rates of day mortality were similar between the two groups In , Eli Lilly announced a voluntary withdrawal of Xigris from markets worldwide, and the FDA withdrew its approval of the drug in the United States. All duels last between 2 and 4 rounds. If after the final round there is no victor then the character with higher Prowess will win.

During a duel either character can gain or lose Duel Edge. Duel Edge will add or substract Prowess to a character for the duration of the duel. During each round both characters will choose one of three random combat moves that are given based on their Prowess. AI characters will choose among the available moves based on their personality:. Special combat moves are either effective or grant additional bonuses but have additional requirements.

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